P-150 Comparison of morphokinetic parameters of embryos generated from Capacitation In-vitro Maturation and Controlled ovarian stimulation-ICSI

Abstract Study question Is there any difference in the embryo morphokinetic parameters between embryos generated from Capacitation – In-vitro maturation (CAPA-IVM) and Controlled ovarian stimulation ICSI (COS-ICSI)? Summary answer Embryos CAPA-IVM cycles reached tPNa, t2, t4, t8, tSC, tM, tSB, tB significantly later than COS-ICSI embryos. What is known already IVF with hyperstimulation has limitations some subgroups of women at high risk stimulation, such as those polycystic ovary syndrome. IVM may be a feasible alternative to AFC. A recent randomized controlled trial produced statistically inconclusive findings regarding noninferiority technique compared COS-ICSI. Moreover, lack studies investigating impact on design, size, duration This retrospective cohort study conducted March 2021 2022. The included 115 couples (68 used CAPA-IVM, 47 COS-ICSI) who had their cultured blastocyst stage using time-lapse system. Participants/materials, setting, methods was My Duc Phu Nhuan hospital, Ho Chi Minh City, Vietnam. Couples aged ≤ 40 years old, culture system were study. oocyte or sperm donation, PGT treatment, severe male factors, fertilization failure previous excluded. We analyzed 392 blastocysts for including tPNf, onset t2 tB. Main results role chance There no t3, t5 However, [tPNa (9.3 2.0 vs 8.0 1.9; P < 0.001), (27.4 3.7 vs. 25.5 3.1; t4 (38.7 4.5 37.3 4.3; = 0.004), t8 (58.9 9.2 56.3 8.4; 0.011), tSC (76.2 11.1 71.4 10.4; tM (90.4 8.6 85.5 10.0; 0.001); tSB (101 8.1 97.1 8.3; 0.001) (108 7.6 106 7.7; 0.05)]. frequency direct cleavage first second cell division cycle similar two groups (58.6% 30.0%; 41.4% 70%, respectively, > 0.05). Limitations, reasons caution design could limit ability eliminate sources bias. characteristics participants influence findings, i.e. group PCOS while not. In addition, population's single-ethnicity nature limits results' external generalizability. Wider implications found that this provide evidence further evaluate improve Trial registration number Not Applicable